Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusionArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antibody approved B cell BCR binding epitope blocked CDR3 contribute described elicited Health humanized immunogen inhibiting Last Lattice mechanism of action membrane fusion mice Modification mouse model neutralization activity neutralize neutralized Neutralizing antibodies neutralizing antibody omicron Pathogens RBD receptor receptor-binding motif Recombination SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant sequence Spike protein therapeutic therapeutic potential Vaccine Wuhan-Hu-1 [DOI] 10.1126/sciimmunol.add5446 PMC 바로가기
Neutralizing Ability of a Single Domain VNAR Antibody: In Vitro Neutralization of SARS-CoV-2 Variants of ConcernArticle Published on 2022-10-142022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Ability ACE2 binding antibody Antibody titer Antigen binding domain binding epitope characterized concern coronavirus 2 coronavirus disease COVID-19 COVID-19 neutralizing antibody Delta domains effective high affinity high stability highlight Infection introduced lung cell Neutralizing neutralizing antibody New omicron pathogen plasma Protein RBD respiratory SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants single-domain antibody Spike protein spike protein. suggested therapeutic option unique variable variant VNAR therapy was tested was used [DOI] 10.3390/ijms232012267 PMC 바로가기
Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron치명적인 SARS-CoV-2 감염 표적 수용체 결합 에피토프로부터 보호하는 나노바디는 오미크론 이외의 바이러스 변이체에 보존되어 있습니다Article Published on 2022-04-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] affinity antibody binding binding epitope binding mode blocked cell cultures cell entry cell entry receptor competition coronavirus COVID-19 COVID-19 pandemic cryo Cryo-electron microscopy electron microscopy Epitopes fusion glycoprotein groups hACE2 heavy chain human ACE2 humanized immune Immune escape immunized lethal mice Microscopy mono MOST nanobodies nanobody neutralization neutralized Neutralizing Neutralizing antibodies neutralizing antibodies. neutralizing antibody nine omicron Other Prevent prevented progression Protecting pseudotyped RBD RBD binding RBM receptor receptor binding motif Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants selected target the receptor-binding domain the S protein therapeutic potential Therapeutics Vaccine variant variants of concern virus virus [DOI] 10.3389/fimmu.2022.863831 PMC 바로가기 [Article Type] Article
Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domain스파이크 수용체 결합 도메인의 특정 에피토프를 표적으로 하는 단일클론항체에 의한 SARS-CoV-2 감염의 중화 또는 증강Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody-dependent enhancement binding binding epitope caused cellular contrary coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity Delta demonstrated dose-dependent manner ELISA epitope Epitopes Epsilon exhibited exhibiting experiment Gamma HEK293T cells Infection lentivirus MERS-CoV monoclonal antibodies monoclonal antibody mouse monoclonal antibody NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody Prophylactic Protein pseudotyped RBD receptor Receptor binding domain Receptor-binding domain reduction Region reported residue residues respiratory S protein S proteins SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike Spike receptor binding domain Spike receptor binding domain. spike receptor-binding domain the RBD the receptor-binding domain the S protein Therapeutic treatment variant variants of SARS-CoV-2 wild-type [DOI] 10.1016/j.antiviral.2022.105290 PMC 바로가기 [Article Type] Article
Allosteric Determinants of the SARS-CoV-2 Spike Protein Binding with Nanobodies: Examining Mechanisms of Mutational Escape and Sensitivity of the Omicron VariantArticle Published on 2022-02-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] ACE2 host receptor ACE2-binding site allosteric interactions Alter Analysis binding binding affinity binding epitope binding free energy biochemical Combination complex complexes computational analysis dependent on determinant detrimental escape escape mutant examined Examining functional generate hotspot induce less mechanism modulation molecular dynamics Molecular simulation Mutation mutational sensitivity nanobodies nanobody network analysis neutralization neutralizing capacity omicron performed Perturbation plasticity Regulatory residues Resilience SARS-CoV-2 spike protein signal transmission spike Spike protein spike trimer supported the SARS-CoV-2 the SARS-CoV-2 virus variant [DOI] 10.3390/ijms23042172 PMC 바로가기 [Article Type] Article
Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBDArticle Published on 2022-02-152022-10-04 Journal: Cell Discovery [Category] 변종, 치료제, [키워드] ACE2 acute respiratory syndrome affinity antibody Autoimmunity Beta binding epitope characterized Contact coronavirus Cryoelectron microscopy Delta eliminated enzyme Epidemic epitope experiment globe high affinity highlight hydrophobic in vitro inhibitory concentration Interaction Microscopy monoclonal antibody Mutation neutralization neutralize neutralized overlap RBD Receptor binding domain rhesus SARS-CoV-2 SARS-CoV-2 variant Spike protein Spike proteins therapeutic therapeutic efficacy therapy Tolerance transgenic mice Transmissibility Vaccine variants of concern viral burden VoC VOCs [DOI] 10.1038/s41421-022-00381-7 PMC 바로가기 [Article Type] Article
An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variantsArticle Published on 2022-02-092022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] amino acid substitutions antibodies antibody B.1.1.529 B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 B.1.621 Beta binding epitope Clinical use convalescent patient Delta determine domain Drug development Effectiveness experiment extension fusing Gamma highlight host adaptation human IgG1 Fc identify IMPROVE Lambda Microbiology Mutation mutations nanobody neutralization breadth neutralization potency neutralize Neutralizing activity neutralizing antibody omicron P.1 RBD RBD mutations SARS-CoV-2 SARS-CoV-2 neutralization activity SARS-CoV-2 variant spike stability tested the RBD therapeutic Transmission Vaccine variant virus [DOI] 10.1038/s41392-022-00912-4 PMC 바로가기 [Article Type] Article
Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjectsResearch Article Published on 2022-01-212022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract Affect affecting approach binding affinity binding epitope characterized cleavage site Community COVID-19 COVID-19 positive subject D614G D614G mutation deep sequencing diffusion effort epitope evidence of evidenced Fiumicino HLA alleles identify immune response implication Infection Italy modulation MONITOR mutated Mutation next generation sequencing objective peptide Protein Proteins reported respiratory sample Result S939F SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants selective Sequencing analysis severity specific mutation spike spike mutations stability subject T-cell triggered unique viral infection was performed was used [DOI] 10.1016/j.csbj.2022.01.021 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 spike protein displays sequence similarities with paramyxovirus surface proteins; a bioinformatics studyResearch Article Published on 2021-12-022022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] analysis Analysis analyzed B cell epitope binding epitope bioinformatics Cell COVID-19 pandemic Evolution Helicase IEDB Immune Epitope Database immunological involved MHC pathogen pathogenic pathogenic coronavirus performed positive potential molecular Protein Proteins recent SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 spike protein Scientific community sequence similarity similarity Spike protein spike protein S2 ssRNA subunit surface protein T cell variant virus viruses VOCs VOIs [DOI] 10.1371/journal.pone.0260360 PMC 바로가기 [Article Type] Research Article